“And the voice of harpers, and musicians, and of pipers, and trumpeters, shall be heard no more at all in thee; and no craftsman, of whatsoever craft he be, shall be found any more in thee; and the sound of a millstone shall be heard no more at all in thee;”
King James Version (KJV)
18:22 And the voice of harpers - Players on stringed instruments. And musicians - Skilful singers in particular. And pipers - Who played on flutes, chiefly on mournful, whereas trumpeters played on joyful, occasions. Shall be heard no more in thee; and no artificer - Arts of every kind, particularly music, sculpture, painting, and statuary, were there carried to their greatest height. No, nor even the sound of a mill - stone shall be heard any more in thee - Not only the arts that adorn life, but even those employments without which it cannot subsist, will cease from thee for ever. All these expressions denote absolute and eternal desolation. The voice of harpers - Music was the entertainment of the rich and great; trade, the business of men of middle rank; preparing bread and the necessaries of life, the employment of the lowest people: marriages, in which lamps and songs were known ceremonies, are the means of peopling cities, as new births supply the place of those that die. The desolation of Rome is therefore described in such a manner, as to show that neither rich nor poor, neither persons of middle rank, nor those of the lowest condition, should be able to live there any more. Neither shall it be repeopled by new marriages, but remain desolate and uninhabited for ever.
Re 18:22 And the voice of harpers. It is this third angel who declares the silence and desolation of the city now. And the sound of a millstone. In the mills grinding food for the people. The mills were hand-mills, usually worked by women as a domestic duty.