“And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.”
King James Version (KJV)
16:2 And the first went - So the second, third, &c., without adding angel, to denote the utmost swiftness; of which this also is a token, that there is no period of time mentioned in the pouring out of each phial. They have a great resemblance to the plagues of Egypt, which the Hebrews generally suppose to have been a month distant from each other. Perhaps so may the phials; but they are all yet to come. And poured out his phial upon the earth - Literally taken. And there came a grievous ulcer - As in Egypt, #Exod 9:10|,11. On the men who had the mark of the wild beast - All of them, and them only. All those plagues seem to be described in proper, not figurative, words.
Re 16:2 THE FIRST VIAL. And the first went, and poured out his vial upon the earth. John sees the vial poured out, and marks its effect; very grievous ulcers fall upon men; that is, upon the men which had the mark of the beast, and [upon] them who worshipped his image. Those who suffer are those who listen to the lamb-like dragon, the anti-Christ, the false spiritual power, or, as has been found in chapter 14, the votaries of Rome.