“And the sixth angel poured out his vial upon the great river Euphrates; and the water thereof was dried up, that the way of the kings of the east might be prepared.”
King James Version (KJV)
16:12 And the sixth poured out his phial upon the great river Euphrates - Affected also by the sixth trumpet. And the water of it - And of all the rivers that flow into it. Was dried up - The far greater part of the Turkish empire lies on this side the Euphrates. The Romish and Mahometan affairs ran nearly parallel to each other for several ages. In the seventh century was Mahomet himself; and, a little before him, Boniface III., with his universal bishopric. In the eleventh, both the Turks and Gregory VII. carried all before them. In the year 1300, Boniface appeared with his two swords at the newly - erected jubilee. In the self - same year arose the Ottoman Porte; yea, and on the same day. And here the phial, poured out on the throne of the beast, is immediately followed by that poured out on the Euphrates; that the way of the kings from the east might be prepared - Those who lie east from the Euphrates, in Persia, India, &c., who will rush blindfold upon the plagues which are ready for them, toward the Holy Land, which lies west of the Euphrates.
Re 16:12 THE SIXTH VIAL. And the sixth angel poured out his vial upon the great river Euphrates; and the water thereof was dried up. The angel of the sixth trumpet is connected with the river Euphrates (Re 9:14). There a movement is symbolized which ends in the overthrow of the Eastern Roman Empire, the old Roman world power. Here a movement is probably signified which will work to the same end in the case of the Roman dominion revived in the Papal world power. The river Euphrates was the seat of the great city which once oppressed Israel and carried God's people into captivity. It was taken by Cyrus, God's chosen agent, and the means employed was the drying up of the Euphrates. Cyrus turned the river, which ran through the city, unto new channels, dried up the old bed, then marched in this bed under the walls where they crossed the river on arches, and took the city. In some way the drying up of the Euphrates shall overthrow, or tend to overthrow, spiritual Babylon. Possibly this may be accomplished by the exhaustion of the resources of that power. The nations which once supplied them have been falling away. That the way might of the kings of the east might be prepared. In the infancy of the Christ, the wise men of the East, also called kings in the Psalms, came to offer homage to the kingly child. The prophecy implies that when this obstacle is removed, the way of the inhabitants shall be opened. The drying up of the Euphrates will, in some manner, open the way for those that are signified to come to Christ, as those of the old did to the manger.