“And I heard a great voice out of the temple saying to the seven angels, Go your ways, and pour out the vials of the wrath of God upon the earth.”
King James Version (KJV)
16:1 Pour out the seven phials - The epistles to the seven churches are divided into three and four: the seven seals, and so the trumpets and phials, into four and three. The trumpets gradually, and in a long tract of time, overthrow the kingdom of the world: the phials destroy chiefly the beast and his followers, with a swift and impetuous force. The four first affect the earth, the sea, the rivers, the sun; the rest fall elsewhere, and are much more terrible.
Re 16:1 The Seven Last Plagues SUMMARY OF REVELATION 16: The Seven Angels Directed to Pour Out God's Wrath. The First Bowl and the Grievous Ulcers. The Second Bowl Poured Out Upon the Sea. The Third Bowl on the Rivers. The Fourth Bowl Upon the Sun. Its Scorching Heat. The Fifth Bowl Poured on the Seat of the Beast. The Sixth Bowl on the Great River Euphrates. The Three Unclean Spirits. Armageddon. The Seventh Bowl Poured on the Air. The Great City Fall. I heard a great voice. As in several more instances John hears the voice, but does not see the speaker. This voice comes out of the temple, from "the tabernacle of the testimony in heaven" (Re 15:5), from the abode of God. This signifies that God's hand will shape the events symbolized. They represent his judgments. Pour out the vials of the wrath of God. Punishment sent for sins. As the plagues were sent on Egypt in order to secure the redemption of Israel, so these plagues are sent in order to redeem God's Israel from the slavery of spiritual Babylon. See Re 18:4. Upon the earth. The term "earth" is still used by John in his usual meaning of the Roman world.