"Acts 18:2; 27:1, 6; Heb. 13:24), like most geographical names," was differently used at different periods of history. As the "power of Rome advanced, nations were successively conquered and" added to it till it came to designate the whole country to the south of the Alps. There was constant intercourse between Palestine and Italy in the time of the Romans.

See where Italy occurs in the Bible...

Definition of Italy:
"abounding with calves or heifers"