"(1.) In Syria, on the river Orontes, about 16 miles from the" "Mediterranean, and some 300 miles north of Jerusalem. It was the" "metropolis of Syria, and afterwards became the capital of the" "Roman province in Asia. It ranked third, after Rome and" "Alexandria, in point of importance, of the cities of the Roman" "empire. It was called the "first city of the East." Christianity" "was early introduced into it (Acts 11:19, 21, 24), and the name" Christian was first applied here to its professors (Acts 11:26). It is intimately connected with the early history of the "gospel (Acts 6:5; 11:19, 27, 28, 30; 12:25; 15:22-35; Gal. 2:11," 12). It was the great central point whence missionaries to the Gentiles were sent forth. It was the birth-place of the famous "Christian father Chrysostom, who died A.D. 407. It bears the" "modern name of Antakia, and is now a miserable, decaying Turkish" "town. Like Philippi, it was raised to the rank of a Roman" "colony. Such colonies were ruled by "praetors" (R.V. marg., Acts" "16:20, 21)." "(2.) In the extreme north of Pisidia; was visited by Paul and Barnabas on the first missionary journey (Acts 13:14). Here they found a synagogue and many proselytes. They met with great "success in preaching the gospel, but the Jews stirred up a" "violent opposition against them, and they were obliged to leave" "the place. On his return, Paul again visited Antioch for the" purpose of confirming the disciples (Acts 14:21). It has been "identified with the modern Yalobatch, lying to the east of" Ephesus.

The name of several Syrian kings from B.C. 280 to B.C. 65. The "most notable of these were, (1.) Antiochus the Great, who" "ascended the throne B.C. 223. He is regarded as the "king of the" "north" referred to in Dan. 11:13-19. He was succeeded (B.C. 187)" "by his son, Seleucus Philopater, spoken of by Daniel (11:20) as" "a raiser of taxes, in the Revised Version, "one that shall" "cause an exactor to pass through the glory of the kingdom." "(2.) Antiochus IV., surnamed "Epiphanes" i.e., the Illustrious, succeeded his brother Seleucus (B.C. 175). His career and character are prophetically described by Daniel (11:21-32). He "was a "vile person." In a spirit of revenge he organized an" "expedition against Jerusalem, which he destroyed, putting vast" multitudes of its inhabitants to death in the most cruel manner. From this time the Jews began the great war of independence "under their heroic Maccabean leaders with marked success," defeating the armies of Antiochus that were sent against them. "Enraged at this, Antiochus marched against them in person," threatening utterly to exterminate the nation; but on the way he was suddenly arrested by the hand of death (B.C. 164).

See where Antioch occurs in the Bible...

Definition of Antioch:
"speedy as a chariot"